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Flunitrazepam, also known as Rohypnol among other names,is an intermediate acting benzodiazepine used in some countries to treat severe insomnia and in fewer, early in anesthesia.As with other hypnotics, flunitrazepam has been advised to be prescribed only on a short-term basis or by those with chronic insomnia on an occasional basis.
It was patented in 1962 and came into medical use in 1974.Flunitrazepam has been referred to as a date rape drug, though the percentage of reported rape cases in which it is involved is small.Adverse effects of flunitrazepam include dependence, both physical and psychological; reduced sleep quality resulting isomnolence; and overdose, resulting in excessive sedation, impairment of balance and speech, respiratory depression or coma, and possibly death. Because of the latter, flunitrazepam is commonly used in suicide.
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Flunitrazepam as with other benzodiazepines can lead to drug dependence and benzodiazepine withdrawal syndrome.Discontinuation may result in the appearance of withdrawal symptoms. Abrupt withdrawal may lead to a benzodiazepine withdrawal syndrome characterised by seizures, psychosis, insomnia, and anxiety. Rebound insomnia, worse than baseline insomnia, typically occurs after discontinuation of flunitrazepam even after short-term single nightly dose therapy.Flunitrazepam produces a decrease in delta wave activity. The effect of benzodiazepine drugs on delta waves, however, may not be mediated via benzodiazepine receptors.
Delta activity is an indicator of depth of sleep within non-REM sleep; increased levels of delta sleep reflects better quality of sleep. Thus, flunitrazepam and other benzodiazepines cause a deterioration in sleep quality. Cyproheptadine may be superior to benzodiazepines in the treatment of insomnia as it enhances sleep quality based on EEG studies.Flunitrazepam may cause a paradoxical reaction in some individuals causing symptoms including anxiety, aggressiveness, agitation, confusion, disinhibition, loss of impulse control, talkativeness, violent behavior, and even convulsions. Rohypnol Powder for sale
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In the United States, imported Rohypnol came to prominence in the 1990s as an inexpensive recreational sedative and a “date rape” drug. The tablets are sold on the street for $0.50 to $5 a piece.
In a single 1- or 2-mg dose, Rohypnol reduces anxiety, inhibition. And muscular tension with a potency that is approximately 10 times that of diazepam (Valium). Higher doses produce anterograde amnesia, lack of muscular control, and loss of consciousness. Effects occur about 30 minutes after ingestion, peak at two hours, and may last up to eight to 12 hours. The effects are much greater with the concurrent ingestion of alcohol or other sedating drugs.
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